A Review on the Disruption of Novel Object Recognition Induced by Methamphetamine

Document Type : Review Article(s)


1 Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2 Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

3 Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran

4 1.Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran 2. Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran



Background: Methamphetamine (MA), is a widely abused synthetic psychostimulant that leads to irreversible brain damage 
manifested as cognitive impairments in humans and animals. The novel object recognition (NOR) task is a commonly used 
behavioral assay for the investigation of non-spatial memory in rodents. This test is based on the natural tendency of rodents to 
spend more time exploring a novel object than a familiar one. NOR test has been used in many studies investigating cognitive 
deficits caused by MA in rodents. The objective of the present study was to review neurobiological mechanisms that might be 
responsible for MA-induced NOR alterations. 
Methods: A PubMed search showed 83 publications using novel object recognition and methamphetamine as keywords in the 
past 10 years. 
Findings: The present study revealed different MA regimens cause recognition memory impairment in rodents. In addition, 
it was found that the main neurobiological mechanism involved in MA-induced recognition deficits is the dysfunction of 
monoaminergic systems. 
Conclusion: NOR is a useful test to assess the cognitive functions following MA administration and evaluate the efficacy of new 
therapeutic agents in MA-addicted individuals.


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