Document Type : Review Article(s)
Authors
1
Tobacco Prevention and Control Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2
Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
3
Departments of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4
Mycobacteriology Research Center, Biostatistics Unit, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5
Tobacco Prevention and Control Research Center,National Institute Tuberculosis and Lung Diseases,Shahid Beheshti University of Medical Sciences, Tehran Iran
Abstract
Background: Varenicline tartrate is a new and selective agonist of the nicotinic acetylcholine receptor. The purpose of this study is to conduct a meta-analysis to determine varenicline efficacy in smoking cessation among hospitalized patients.
Methods: We looked through worldwide databases such as Web of Science, Embase, PubMed, Cochrane, and Scopus. Relevant pieces of research published on varenicline efficacy on smoking cessation among hospitalized patients were discovered using proper keywords. The software Stata version 14 and random-effects model meta-analysis were used to analyze the data.
Results: Nine studies were eligible to be included in this study, with a total sample size of 2131. Generally, the point abstinence rate was significantly greater in the varenicline group compared with that in the placebo at week 12 (OR = 0.59; 95% CI: 053-0.65; p <0.001), 24 (OR = 0.78; 95% CI: 0.72-0.84; p <0.001), and 52 (OR = 0.86; 95% CI: 0.80-0.92; p <0.001). Furthermore, the continuous abstinence rate for week 4 (OR = 0.70; 95% CI: 019-0.54; P = 0.000), 12 (OR = 0.26; 95% CI: 019-0.54; p <0.001), 24 (OR = 0.32; 95% CI: 019-0.53; p <0.001) and 52 (OR = 0.32; 95% CI: 019-0.54; p <0.001) was significantly greater in the varenicline group compared with that in the placebo.
Conclusion: According to the high efficacy of varenicline in both short and long-term smoking settings and considering the importance of smoking cessation in the high-risk hospitalized patients, varenicline consumption could be considered as a main smoking cessation strategy in these patients.
Keywords
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