1. Parvaresh N, Mazhari S, Nazari-Noghabi M. Frequency
of psychiatric disorders in children of opioid or
methamphetamine-dependent patients. Addict Health.
2015;7(3-4):140-8.
2. Azadfard M, Huecker MR, Leaming JM. Opioid addiction. In:
StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing;
2022.
3. Theisen K, Jacobs B, Macleod L, Davies B. The United States
opioid epidemic: a review of the surgeon’s contribution to it
and health policy initiatives. BJU Int. 2018;122(5):754-9. doi:
10.1111/bju.14446.
4. Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug
self-administration: implications for addiction comorbidity
with post-traumatic stress disorder. Neuropharmacology.
2012;62(2):552-64. doi: 10.1016/j.neuropharm.2011.07.007.
5. Christoffersen MN, Soothill K. The long-term consequences of
parental alcohol abuse: a cohort study of children in Denmark.
J Subst Abuse Treat. 2003;25(2):107-16. doi: 10.1016/s0740-
5472(03)00116-8.
6. Young NK, Boles SM, Otero C. Parental substance use
disorders and child maltreatment: overlap, gaps, and
opportunities. Child Maltreat. 2007;12(2):137-49. doi:
10.1177/1077559507300322.
7. Yalçın B, Pomrenze MB, Malacon K, Chau IJ, Taylor KR,
Ni L, et al. Myelin plasticity in ventral tegmental area is
required for opioid reward. bioRxiv [Preprint]. September
3, 2022. Available from: https://www.biorxiv.org/
content/10.1101/2022.09.01.506263v1.
8. Steiner S, Schori D, Gmel G. Excessive alcohol consumption
in young men: is there an association with their earlier family
situation? A baseline-analysis of the C-SURF-study (Cohort
Study on Substance Use Risk Factors). Swiss Med Wkly.
2014;144:w14007. doi: 10.4414/smw.2014.14007.
9. Parvaz MA, Kim K, Froudist-Walsh S, Newcorn JH, Ivanov I.
Reward-based learning as a function of severity of substance
abuse risk in drug-naïve youth with ADHD. J Child Adolesc
Psychopharmacol. 2018;28(8):547-53. doi: 10.1089/
cap.2018.0010.
10. McCutcheon VV, Scherrer JF, Grant JD, Xian H, Haber
JR, Jacob T, et al. Parent, sibling and peer associations
with subtypes of psychiatric and substance use disorder
comorbidity in offspring. Drug Alcohol Depend. 2013;128(1-
2):20-9. doi: 10.1016/j.drugalcdep.2012.07.015.
11. Hoffmann JP, Cerbone FG. Parental substance use disorder
and the risk of adolescent drug abuse: an event history
analysis. Drug Alcohol Depend. 2002;66(3):255-64. doi:
10.1016/s0376-8716(02)00005-4.
12. Hanson RF, Self-Brown S, Fricker-Elhai A, Kilpatrick DG,
Saunders BE, Resnick H. Relations among parental substance
use, violence exposure and mental health: the national survey
of adolescents. Addict Behav. 2006;31(11):1988-2001. doi:
10.1016/j.addbeh.2006.01.012.
13. Cummings JR, Lumeng JC, Miller AL, Hyde LW, Siada R,
Gearhardt AN. Parental substance use and child rewarddriven eating behaviors. Appetite. 2020;144:104486. doi:
10.1016/j.appet.2019.104486.
14. Bornovalova MA, Hicks BM, Iacono WG, McGue M. Familial
transmission and heritability of childhood disruptive disorders.
Am J Psychiatry. 2010;167(9):1066-74. doi: 10.1176/appi.
ajp.2010.09091272.
15. Tennant C, Bernardi E. Childhood loss in alcoholics and
narcotic addicts. Br J Addict. 1988;83(6):695-703. doi:
10.1111/j.1360-0443.1988.tb02600.x.
16. Bekir P, McLellan T, Childress AR, Gariti P. Role reversals
in families of substance misusers: a transgenerational
phenomenon. Int J Addict. 1993;28(7):613-30. doi:
10.3109/10826089309039652.
17. Penttinen R, Hakko H, Riipinen P, Isohookana R, Riala K.
Associations of adverse childhood experiences to smoking
and nicotine dependence among adolescent psychiatric
inpatients. Community Ment Health J. 2020;56(2):333-7. doi:
10.1007/s10597-019-00476-8.
18. Romanowicz M, Vande Voort JL, Shekunov J, Oesterle TS,
Thusius NJ, Rummans TA, et al. The effects of parental
opioid use on the parent-child relationship and children’s
developmental and behavioral outcomes: a systematic review
of published reports. Child Adolesc Psychiatry Ment Health.
2019;13:5. doi: 10.1186/s13034-019-0266-3.
19. Vargas GC, Pildes RS, Vidyasagar D, Keith LG. Effect
of maternal heroin addiction on 67 liveborn neonates.
Withdrawal symptoms, small body size, and small head
circumference were frequent findings. Clin Pediatr (Phila).
1975;14(8):751-7. doi: 10.1177/000992287501400811.
20. Furukawa T, Harai H, Hirai T, Fujihara S, Kitamura
T, Takahashi K. Childhood parental loss and alcohol
dependence among Japanese men: a case-control study.
Group for Longitudinal Affective Disorders Study (GLADS).
Acta Psychiatr Scand. 1998;97(6):403-7. doi: 10.1111/j.1600-
0447.1998.tb10022.x.
21. Weissman MM, Warner V, Wickramaratne PJ, Kandel DB.
Maternal smoking during pregnancy and psychopathology in
offspring followed to adulthood. J Am Acad Child Adolesc
Psychiatry. 1999;38(7):892-9. doi: 10.1097/00004583-
199907000-00020.
22. Biederman J, Faraone SV, Monuteaux MC, Feighner JA.
Patterns of alcohol and drug use in adolescents can be
predicted by parental substance use disorders. Pediatrics.
2000;106(4):792-7. doi: 10.1542/peds.106.4.792.
23. Dawe S, Harnett PH, Rendalls V, Staiger P. Improving family functioning and child outcome in methadonemaintained families: the Parents Under Pressure
programme. Drug Alcohol Rev. 2003;22(3):299-307. doi:
10.1080/0959523031000154445.
24. Ohannessian CM, Hesselbrock VM, Kramer J, Bucholz KK,
Schuckit MA, Kuperman S, et al. Parental substance use
consequences and adolescent psychopathology. J Stud
Alcohol. 2004;65(6):725-30. doi: 10.15288/jsa.2004.65.725.
25. Vazquez V, Penit-Soria J, Durand C, Besson MJ, Giros B,
Daugé V. Maternal deprivation increases vulnerability to
morphine dependence and disturbs the enkephalinergic
system in adulthood. J Neurosci. 2005;25(18):4453-62. doi:
10.1523/jneurosci.4807-04.2005.
26. Vazquez V, Giros B, Daugé V. Maternal deprivation
specifically enhances vulnerability to opiate dependence.
Behav Pharmacol. 2006;17(8):715-24. doi: 10.1097/
FBP.0b013e3280116e6f.
27. Vazquez V, Weiss S, Giros B, Martres MP, Daugé V. Maternal
deprivation and handling modify the effect of the dopamine
D3 receptor agonist, BP 897 on morphine-conditioned
place preference in rats. Psychopharmacology (Berl).
2007;193(4):475-86. doi: 10.1007/s00213-007-0789-9.
28. Vucinovic M, Roje D, Vucinovic Z, Capkun V, Bucat M,
Banovic I. Maternal and neonatal effects of substance abuse
during pregnancy: our ten-year experience. Yonsei Med J.
2008;49(5):705-13. doi: 10.3349/ymj.2008.49.5.705.
29. Morel LJ, Giros B, Daugé V. Adolescent exposure to chronic
delta-9-tetrahydrocannabinol blocks opiate dependence
in maternally deprived rats. Neuropsychopharmacology.
2009;34(11):2469-76. doi: 10.1038/npp.2009.70.
30. Newman TK, Parker CC, Suomi SJ, Goldman D, Barr CS,
Higley JD. DRD1 5’UTR variation, sex and early infant
stress influence ethanol consumption in rhesus macaques.
Genes Brain Behav. 2009;8(6):626-30. doi: 10.1111/j.1601-
183X.2009.00507.x.
31. Naudon L, Piscitelli F, Giros B, Di Marzo V, Daugé V. Possible
involvement of endocannabinoids in the increase of morphine
consumption in maternally deprived rat. Neuropharmacology.
2013;65:193-9. doi: 10.1016/j.neuropharm.2012.10.008.
32. Chuang E, Wells R, Bellettiere J, Cross TP. Identifying the
substance abuse treatment needs of caregivers involved with
child welfare. J Subst Abuse Treat. 2013;45(1):118-25. doi:
10.1016/j.jsat.2013.01.007.
33. Yule AM, Wilens TE, Martelon MK, Simon A, Biederman J.
Does exposure to parental substance use disorders increase
substance use disorder risk in offspring? A 5-year follow-up
study. Am J Addict. 2013;22(5):460-5. doi: 10.1111/j.1521-
0391.2013.12048.x.
34. Stice E, Yokum S. Brain reward region responsivity of
adolescents with and without parental substance use
disorders. Psychol Addict Behav. 2014;28(3):805-15. doi:
10.1037/a0034460.
35. Secco L, Letourneau N, Campbell MA, Craig S, Colpitts J.
Stresses, strengths, and experiences of mothers engaged
in methadone maintenance treatment. J Addict Nurs.
2014;25(3):139-47. doi: 10.1097/jan.0000000000000038.
36. O’Brien JW, Hill SY. Effects of prenatal alcohol and cigarette
exposure on offspring substance use in multiplex, alcoholdependent families. Alcohol Clin Exp Res. 2014;38(12):2952-
61. doi: 10.1111/acer.12569.
37. Yule AM, Wilens TE, Martelon M, Rosenthal L, Biederman J.
Does exposure to parental substance use disorders increase
offspring risk for a substance use disorder? A longitudinal
follow-up study into young adulthood. Drug Alcohol Depend.
2018;186:154-8. doi: 10.1016/j.drugalcdep.2018.01.021.
38. Amancio-Belmont O, Becerril Meléndez AL, Ruiz-Contreras
AE, Méndez-Díaz M, Prospéro-García O. Opposed
cannabinoid 1 receptor (CB1R) expression in the prefrontal
cortex vs. nucleus accumbens is associated with alcohol
consumption in male rats. Brain Res. 2019;1725:146485. doi:
10.1016/j.brainres.2019.146485.
39. Amancio-Belmont O, Becerril Meléndez AL, Ruiz-Contreras
AE, Méndez-Díaz M, Prospéro-García O. Maternal separation
plus social isolation during adolescence reprogram brain
dopamine and endocannabinoid systems and facilitate
alcohol intake in rats. Brain Res Bull. 2020;164:21-8. doi:
10.1016/j.brainresbull.2020.08.002.
40. Hans SL, Bernstein VJ, Henson LG. The role of
psychopathology in the parenting of drug-dependent women.
Dev Psychopathol. 1999;11(4):957-77. doi: 10.1017/
s0954579499002400.
41. Pautassi RM, Camarini R, Quadros IM, Miczek KA, Israel
Y. Genetic and environmental influences on ethanol
consumption: perspectives from preclinical research. Alcohol
Clin Exp Res. 2010;34(6):976-87. doi: 10.1111/j.1530-
0277.2010.01172.x.
42. Jansson LM, Dipietro JA, Elko A, Velez M. Maternal vagal
tone change in response to methadone is associated with
neonatal abstinence syndrome severity in exposed neonates.
J Matern Fetal Neonatal Med. 2007;20(9):677-85. doi:
10.1080/14767050701490327.
43. Le TL, Kenaszchuk C, Milligan K, Urbanoski K. Levels and
predictors of participation in integrated treatment programs
for pregnant and parenting women with problematic
substance use. BMC Public Health. 2019;19(1):154. doi:
10.1186/s12889-019-6455-4.
44. Flykt MS, Salo S, Pajulo M. “A window of opportunity”:
parenting and addiction in the context of pregnancy. Curr
Addict Rep. 2021;8(4):578-94. doi: 10.1007/s40429-021-
00394-4.
45. Conradt E, Camerota M, Maylott S, Lester BM. Annual
Research Review: prenatal opioid exposure - a two-generation
approach to conceptualizing neurodevelopmental outcomes.
J Child Psychol Psychiatry. 2023;64(4):566-78. doi: 10.1111/
jcpp.13761.
46. Sánchez MM, Ladd CO, Plotsky PM. Early adverse experience
as a developmental risk factor for later psychopathology:
evidence from rodent and primate models. Dev Psychopathol.
2001;13(3):419-49. doi: 10.1017/s0954579401003029.
47. Courtiol E, Wilson DA, Shah R, Sullivan RM, Teixeira CM.
Maternal regulation of pups’ cortical activity: role of serotonergic
signaling. eNeuro. 2018;5(4):ENEURO.0093-18.2018. doi:
10.1523/eneuro.0093-18.2018.
48. Wang X, Wang X, Xie F, Sun Z, Guo B, Li F, et al. Leucine
mediates cognitive dysfunction in early life stress-induced
mental disorders by activating autophagy. Front Cell Neurosci.
2022;16:1060712. doi: 10.3389/fncel.2022.1060712.
49. Zimmerberg B, Sageser KA. Comparison of two rodent
models of maternal separation on juvenile social behavior.
Front Psychiatry. 2011;2:39. doi: 10.3389/fpsyt.2011.00039.
50. Fadaei-Kenarsary M, Esmaeilpour K, Shabani M, Joushi
S, Sheibani V. Chronic morphine exposure and maternal
separation induce impairments in cognition and locomotor
activity of male adolescent rats. Int J Dev Neurosci.
2023;83(3):235-47. doi: 10.1002/jdn.10251.
51. Heydari A, Esmaeilpour K, Sheibani V. Maternal separation
impairs long term-potentiation in CA3-CA1 synapses in
adolescent female rats. Behav Brain Res. 2019;376:112239.
doi: 10.1016/j.bbr.2019.112239.
52. Shahraki S, Esmaeilpour K, Shabani M, Sepehri G, Rajizadeh
MA, Maneshian M, et al. Choline chloride modulates
learning, memory, and synaptic plasticity impairments in maternally separated adolescent male rats. Int J Dev Neurosci.
2022;82(1):19-38. doi: 10.1002/jdn.10155.
53. Talani G, Biggio F, Gorule AA, Licheri V, Saolini E,
Colombo D, et al. Sex-dependent changes of hippocampal
synaptic plasticity and cognitive performance in C57BL/6J
mice exposed to neonatal repeated maternal separation.
Neuropharmacology. 2023;222:109301. doi: 10.1016/j.
neuropharm.2022.109301.
54. Johnson JL, Buisman-Pijlman FT. Adversity impacting on
oxytocin and behaviour: timing matters. Behav Pharmacol.
2016;27(8):659-71. doi: 10.1097/fbp.0000000000000269.
55. Roman E, Gustafsson L, Hyytiä P, Nylander I. Short and
prolonged periods of maternal separation and voluntary ethanol
intake in male and female ethanol-preferring AA and ethanolavoiding ANA rats. Alcohol Clin Exp Res. 2005;29(4):591-
601. doi: 10.1097/01.alc.0000158933.70242.fc.
56. de Oliveira C, Scarabelot VL, Vercelino R, Silveira NP,
Adachi LNS, Regner GG, et al. Morphine exposure and
maternal deprivation during the early postnatal period
alter neuromotor development and nerve growth factor
levels. Int J Dev Neurosci. 2017;63:8-15. doi: 10.1016/j.
ijdevneu.2017.09.001.
57. Masrouri H, Azadi M, Semnanian S, Azizi H. Early life maternal
deprivation attenuates morphine induced inhibition in lateral
paragigantocellularis neurons in adult rats. Brain Res Bull.
2021;169:128-35. doi: 10.1016/j.brainresbull.2021.01.011.
58. Abelaira HM, Rosa T, de Moura AB, Andrade NM, Martinello
NS, Maciel LR, et al. Combination of electroconvulsive
stimulation with ketamine or escitalopram protects the
brain against inflammation and oxidative stress induced by
maternal deprivation and is critical for associated behaviors
in male and female rats. Mol Neurobiol. 2022;59(3):1452-75.
doi: 10.1007/s12035-021-02718-x.
59. Bachiller S, Paulus A, Vázquez-Reyes S, García-Domínguez
I, Deierborg T. Maternal separation leads to regional
hippocampal microglial activation and alters the behavior in
the adolescence in a sex-specific manner. Brain Behav Immun
Health. 2020;9:100142. doi: 10.1016/j.bbih.2020.100142.
60. Fadaei-Kenarsary M, Esmaeilpour K, Shabani M, Sheibani V.
Chronic maternal morphine exposure and early-life adversity
induce impairment in synaptic plasticity of adolescent
male rats. Neurosci Lett. 2023;812:137365. doi: 10.1016/j.
neulet.2023.137365.
61. Čater M, Majdič G. How early maternal deprivation changes
the brain and behavior? Eur J Neurosci. 2022;55(9-10):2058-
75. doi: 10.1111/ejn.15238.
62. Mejía-Chávez S, Venebra-Muñoz A, García-García F, CoronaMorales AA, Orozco-Vargas AE. Maternal separation modifies
the activity of social processing brain nuclei upon social
novelty exposure. Front Behav Neurosci. 2021;15:651263.
doi: 10.3389/fnbeh.2021.651263.
63. Sheehan TP, Chambers RA, Russell DS. Regulation of affect
by the lateral septum: implications for neuropsychiatry.
Brain Res Brain Res Rev. 2004;46(1):71-117. doi: 10.1016/j.
brainresrev.2004.04.009.
64. Orikasa C. Social network plasticity of mice parental
behavior. Front Neurosci. 2022;16:882850. doi: 10.3389/
fnins.2022.882850.
65. Linsambarth S, Moraga-Amaro R, Quintana-Donoso D, Rojas
S, Stehberg J. The amygdala and anxiety. In: Ferry B, ed. The
Amygdala. Rijeka: IntechOpen; 2017. p. 7. doi: 10.5772/
intechopen.68618.
66. Cox R. Differential effects of parents and peers on externalizing
behavior and drug use. Acta Investig Psicol. 2014;4(2):1491-
509. doi: 10.1016/s2007-4719(14)70389-8.
67. Hill SY, Shen S, Locke Wellman J, Rickin E, Lowers L. Offspring
from families at high risk for alcohol dependence: increased
body mass index in association with prenatal exposure to
cigarettes but not alcohol. Psychiatry Res. 2005;135(3):203-
16. doi: 10.1016/j.psychres.2005.04.003.
68. Marmorstein NR, Iacono WG, McGue M. Alcohol and illicit
drug dependence among parents: associations with offspring
externalizing disorders. Psychol Med. 2009;39(1):149-55.
doi: 10.1017/s0033291708003085.
69. Suri D, Bhattacharya A, Vaidya VA. Early stress evokes
temporally distinct consequences on the hippocampal
transcriptome, anxiety and cognitive behaviour. Int J
Neuropsychopharmacol. 2014;17(2):289-301. doi: 10.1017/
s1461145713001004.
70. Viveros MP, Llorente R, Suarez J, Llorente-Berzal A, LópezGallardo M, de Fonseca FR. The endocannabinoid system
in critical neurodevelopmental periods: sex differences
and neuropsychiatric implications. J Psychopharmacol.
2012;26(1):164-76. doi: 10.1177/0269881111408956.
71. Jawahar MC, Murgatroyd C, Harrison EL, Baune BT. Epigenetic
alterations following early postnatal stress: a review on novel
aetiological mechanisms of common psychiatric disorders.
Clin Epigenetics. 2015;7:122. doi: 10.1186/s13148-015-
0156-3.
72. Zhang TY, Labonté B, Wen XL, Turecki G, Meaney MJ.
Epigenetic mechanisms for the early environmental regulation
of hippocampal glucocorticoid receptor gene expression
in rodents and humans. Neuropsychopharmacology.
2013;38(1):111-23. doi: 10.1038/npp.2012.149.
73. Joushi S, Esmaeilpour K, Taherizadeh Z, Taheri F, Sheibani
V. Intergenerational effects of maternal separation on
cognitive abilities of adolescent rats. Int J Dev Neurosci.
2020;80(8):687-98. doi: 10.1002/jdn.10066.
74. Sun H, Zhang X, Kong Y, Gou L, Lian B, Wang Y, et al. Maternal
separation-induced histone acetylation correlates with BDNFprogrammed synaptic changes in an animal model of PTSD
with sex differences. Mol Neurobiol. 2021;58(4):1738-54.
doi: 10.1007/s12035-020-02224-6.
75. Lundgaard Donovan L, Henningsen K, Flou Kristensen
A, Wiborg O, Nieland JD, Lichota J. Maternal separation
followed by chronic mild stress in adulthood is associated
with concerted epigenetic regulation of AP-1 complex genes.
J Pers Med. 2021;11(3):209. doi: 10.3390/jpm11030209.
76. Korosi A, Baram TZ. The pathways from mother’s love
to baby’s future. Front Behav Neurosci. 2009;3:27. doi:
10.3389/neuro.08.027.2009.
77. Kalinichev M, Easterling KW, Holtzman SG. Early neonatal
experience of Long-Evans rats results in long-lasting changes
in morphine tolerance and dependence. Psychopharmacology
(Berl). 2001;157(3):305-12. doi: 10.1007/s002130100806.
78. Matthews K, Robbins TW. Early experience as a determinant of
adult behavioural responses to reward: the effects of repeated
maternal separation in the rat. Neurosci Biobehav Rev.
2003;27(1-2):45-55. doi: 10.1016/s0149-7634(03)00008-3.
79. Arborelius L, Hawks BW, Owens MJ, Plotsky PM, Nemeroff
CB. Increased responsiveness of presumed 5-HT cells to
citalopram in adult rats subjected to prolonged maternal
separation relative to brief separation. Psychopharmacology
(Berl). 2004;176(3-4):248-55. doi: 10.1007/s00213-004-
1883-x.
80. Advani T, Hensler JG, Koek W. Effect of early rearing
conditions on alcohol drinking and 5-HT1A receptor
function in C57BL/6J mice. Int J Neuropsychopharmacol.
2007;10(5):595-607. doi: 10.1017/s1461145706007401.
81. Sachs BD, Tran HL, Folse E, Caron MG. Brain-region-specific
molecular responses to maternal separation and social
defeat stress in mice. Neuroscience. 2018;373:122-36. doi:10.1016/j.neuroscience.2018.01.018.
82. Vazquez DM, Bailey C, Dent GW, Okimoto DK, Steffek
A, López JF, et al. Brain corticotropin-releasing hormone
(CRH) circuits in the developing rat: effect of maternal
deprivation. Brain Res. 2006;1121(1):83-94. doi: 10.1016/j.
brainres.2006.08.104.
83. Cirulli F, Laviola G. Paradoxical effects of D-amphetamine in
infant and adolescent mice: role of gender and environmental
risk factors. Neurosci Biobehav Rev. 2000;24(1):73-84. doi:
10.1016/s0149-7634(99)00047-0.
84. Abbink MR, van Deijk AF, Heine VM, Verheijen MH, Korosi
A. The involvement of astrocytes in early-life adversity
induced programming of the brain. Glia. 2019;67(9):1637-
53. doi: 10.1002/glia.23625.
85. Furukawa M, Tsukahara T, Tomita K, Iwai H, Sonomura
T, Miyawaki S, et al. Neonatal maternal separation delays
the GABA excitatory-to-inhibitory functional switch by
inhibiting KCC2 expression. Biochem Biophys Res Commun.
2017;493(3):1243-9. doi: 10.1016/j.bbrc.2017.09.143.
86. Sarkar T, Patro N, Patro IK. Cumulative multiple early life hits- a
potent threat leading to neurological disorders. Brain Res Bull.
2019;147:58-68. doi: 10.1016/j.brainresbull.2019.02.005.
87. Fadaei-Kenarsary M, Fathi Moghaddam H, Mansouri SM,
Farbood Y. Administration of venlafaxine after chronic
methadone detoxification blocks post-depression relapse
in rats. Braz Arch Biol Technol. 2017;60:e17160436. doi:
10.1590/1678-4324-2017160436.
88. Barr JA. Postpartum depression, delayed maternal adaptation,
and mechanical infant caring: a phenomenological
hermeneutic study. Int J Nurs Stud. 2008;45(3):362-9. doi:
10.1016/j.ijnurstu.2006.10.002.
89. Abelaira HM, Réus GZ, Ribeiro KF, Zappellini G, Cipriano
AL, Scaini G, et al. Lamotrigine treatment reverses depressivelike behavior and alters BDNF levels in the brains of
maternally deprived adult rats. Pharmacol Biochem Behav.
2012;101(3):348-53. doi: 10.1016/j.pbb.2012.01.019.
90. Abelaira HM, Veron DC, de Moura AB, Carlessi AS, Borba
LA, Botelho ME, et al. Sex differences on the behavior
and oxidative stress after ketamine treatment in adult rats
subjected to early life stress. Brain Res Bull. 2021;172:129-
38. doi: 10.1016/j.brainresbull.2021.04.021.
91. Ahmad M, Abu Taweel GM. Ameliorating effects of lithium
on the perinatal ethanol-induced behavioral and cognitive
dysfunction and brain oxidative stress in postnatal developing
mice pups. Curr Pharm Biotechnol. 2020;21(13):1325-32.
doi: 10.2174/1389201021666200615170644.
92. Moreno Gudiño H, Carías Picón D, de Brugada Sauras
I. Dietary choline during periadolescence attenuates
cognitive damage caused by neonatal maternal separation
in male rats. Nutr Neurosci. 2017;20(6):327-35. doi:
10.1080/1028415x.2015.1126444.
93. Taplin S, Mattick RP. Mothers in methadone treatment
and their involvement with the child protection system:
a replication and extension study. Child Abuse Negl.
2013;37(8):500-10. doi: 10.1016/j.chiabu.2013.01.003.
94. Mohammadian J, Najafi M, Miladi-Gorji H. Effect of enriched
environment during adolescence on spatial learning and
memory, and voluntary consumption of morphine in
maternally separated rats in adulthood. Dev Psychobiol.
2019;61(4):615-25. doi: 10.1002/dev.21808.
95. Macartney EL, Lagisz M, Nakagawa S. The relative benefits
of environmental enrichment on learning and memory are
greater when stressed: a meta-analysis of interactions in
rodents. Neurosci Biobehav Rev. 2022;135:104554. doi:
10.1016/j.neubiorev.2022.104554.
96. Naninck EF, Oosterink JE, Yam KY, de Vries LP, Schierbeek H,
van Goudoever JB, et al. Early micronutrient supplementation
protects against early stress-induced cognitive impairments.
FASEB J. 2017;31(2):505-18. doi: 10.1096/fj.201600834R.
97. McGovern R, Newham JJ, Addison MT, Hickman M, Kaner
EF. Effectiveness of psychosocial interventions for reducing
parental substance misuse. Cochrane Database Syst Rev.
2021;3(3):CD012823. doi: 10.1002/14651858.CD012823.
pub2.
98. Montagud-Romero S, Cantacorps L, Valverde O. Histone
deacetylases inhibitor trichostatin A reverses anxiety-like
symptoms and memory impairments induced by maternal
binge alcohol drinking in mice. J Psychopharmacol.
2019;33(12):1573-87. doi: 10.1177/0269881119857208.
99. Garcia VA, Hirotsu C, Matos G, Alvarenga T, Pires GN,
Kapczinski F, et al. Modafinil ameliorates cognitive deficits
induced by maternal separation and sleep deprivation. Behav
Brain Res. 2013;253:274-9. doi: 10.1016/j.bbr.2013.07.029.
100. Moffett MC, Harley J, Francis D, Sanghani SP, Davis WI,
Kuhar MJ. Maternal separation and handling affects cocaine
self-administration in both the treated pups as adults and
the dams. J Pharmacol Exp Ther. 2006;317(3):1210-8. doi:
10.1124/jpet.106.101139.
101. Campbell J, Spear LP. Effects of early handling on
amphetamine-induced locomotor activation and conditioned
place preference in the adult rat. Psychopharmacology (Berl).
1999;143(2):183-9. doi: 10.1007/s002130050934.
102. Malamitsi-Puchner A, Boutsikou T. Adolescent pregnancy
and perinatal outcome. Pediatr Endocrinol Rev. 2006;3 Suppl
1:170-1.
)