Factors Determining Primary Coronary Slow Flow Phenomenon among Opium Users and Non-users: A Case Control Study in Northern Iran

Document Type : Original Article

Authors

1 Department of Cardiology, Bu Ali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

2 Department of Clinical Toxicology, Bu Ali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

3 Department of Infectious Diseases, Bu Ali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran

10.34172/ahj.2022.1211

Abstract

Background: Coronary slow flow phenomenon (CSFP) represents a clinical entity with recurrent chest pain leading to living 
impairment. The present study aimed to investigate whether opium use correlates with primary CSFP.

Methods: This study included Iranian patients with suspected coronary artery disease who underwent myocardial perfusion 
imaging. Coronary blood flow was measured quantitatively using the thrombolysis in myocardial infarction (TIMI) frame count 
and slow flow was defined as TIMI grade 2 standard deviations. Age and clinical conditions including diabetes mellitus (DM), 
hypertension (HTN), hyperlipidemia (HLP), history of chest pain, and opium use were recorded. First, the characteristics of the two 
groups were compared and then the main analyses were conducted to examine the relationship between CSFP and opium use. 
Data were analyzed using t test and chi-square test via SPSS 25.0. The significance level was set at P<0.05.

Findings: This study was conducted on 44 male patients with documented CSFP who had no stenotic lesions and 134 control 
group male patients who had normal coronary arteries with normal flow. The mean age was similar in the two groups (54.25 
vs.52.69, P=0.474). Two groups were significantly different in terms of history of chest pain (P=0.003), but there was no significant 
difference in HTN (P=0.084), DM (P=0.284), HLP (P=0.183), smoking (P=0.696), and opium use (P=0.107). 

Conclusion: This study indicated that opium use is not associated with primary CSFP.

Keywords

Addiction & Health
Volume 14, Issue 3
July 2022
Pages 224-28

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