Document Type : Original Article
Neuroscience Research Center, Institute of Neuropharmacology AND Department of Psychiatry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Neurology Research Center AND Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Department of Psychiatry, Afzalipour School of Medicine AND Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Background: Cognitive impairment in drug users is a marker for predicting recurrence and poorer adherence
to treatment. The purpose of this study was to compare the cognitive function in three groups of methadone
users methadone maintenance treatment (MMT), compared to methadone and methamphetamine (MAMP)
users (MMT + MAMP) and healthy people (control group).
Methods: Three groups of 90 people including 30 users of MMT, 30 users of MMT + MAMP, and 30 healthy
persons participated in this cross-sectional and purposeful study. The study was performed on outpatients of
MMT Clinic of Psychiatric Hospital in Kerman, Iran. The demographic and related data questionnaire was
filled out. In addition, Persian version of the Brief Assessment of Cognition in Schizophrenia (BACS) was
used to assess cognitive function.
Findings: The mean of total number of scores and all BACS subscales were significantly better in control
group than the other two groups of patients. Moreover, not only the mean of total number of BACS was
significantly different between two substance abuser groups, but also there was a significant difference
between them on verbal memory, digit sequencing, and token motor test, with MMT + MAMP group
performing worse than MMT group.
Conclusion: Concomitant use of opioids and stimulant substance such as MAMP results in cumulative toxic
effect of them on brain and cognitive functions.