Correlation among the Behavioral Features in the Offspring of Morphine-Abstinent Rats

Document Type : Original Article


1 Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran

2 Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran AND Department of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran

3 Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Biology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran

5 Department of Pharmacology, School of Medicine AND Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran


Background: Critical analysis of new evidence in medical sciences relies on statistics in terms of correlation.
The aim of the present study was to evaluate the correlation coefficients among the behavioral features in the
offspring of morphine-abstinent parent(s).
Methods: The offspring of various types of parental morphine-exposure were divided into 4 groups including
offspring of healthy parents (CTL), offspring of paternal morphine-abstinence (PMA), offspring of maternal
morphine-abstinence (MMA), and offspring of both morphine-abstinence (BMA). Pain perception,
depression-like behavior, and avoidance memory in the offspring were quantified. The logical structure of
association was measured using the Pearson correlation analysis.
Findings: A strong correlation was observed between pain and depressive-like behavior in female and male
offspring of healthy parents. Moreover, in the male and female offspring of healthy parents and BMA, no
significant correlation was observed between avoidance memory and pain behavior or depressive-like
behavior. However, in the offspring of MMA, a strong correlation was observed between avoidance memory
and depressive-like behavior.
Conclusion: The results of the study signified the importance of correlation analysis in addictive behavior. The
results revealed that the pattern of correlation of the behavior of the offspring of MMA and PMA differed


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