B12 and Folate Concentrations in Opium Addicts Compared to Healthy Subjects: A Case Control Study from Kerman Coronary Artery Disease Risk Study

Document Type : Short Communication(s)


1 Professor, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

2 Assistant Professor, Cardiology Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 Assistant Professor, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

4 Professor, Physiology Research Center AND Department of Physiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran


Background: Opium addiction is a global problem which has implicated many societies. Opium addiction and drug abuse is related to harmful consequences which affect life style, biochemical factors, and vitamins values, and also is considered as a risk for heart diseases. Folate and B12 levels are related to homocysteine and studies about their levels in opium addicts are controversial; therefore, we designed this study to evaluate B12 and folate values in opium addicts. Methods: From the Kerman Coronary Artery Disease Risk Study (KERCADRS) which is a population-based study, we randomly selected 340 men and entered them into two groups: case (n = 170) and control group (n = 170). Then vitamin B12 and folate levels were measured. Findings: Opium addiction did not change B12 and folate levels significantly in opium addicts compared to non-addict control subjects. However, only some variables including blood pressure (BP) and diabetes positively and cigarette smoking, triglyceride (TG), alcohol, and cardiovascular disease (CVD) history negatively affected folate, and none of clinical and demographic variables influenced the B12 levels (P > 0.050). TG had significant effects on B12 and folate levels although opium addiction did not show any impact. Conclusion: High TG levels were accompanied by low levels of B12 and folate. Reduced B12 and folate values are accompanied by serum homocysteine elevation. As TG elevates in opium addicts, it can be considered as an important factor which affects vitamins levels and reduces their absorption. Opium addiction elevates homocysteine level, since we can conclude that homocysteine elevation in opium addicts is independent of B12 and folate levels


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