Kerman University of Medical Sciences

Document Type: Short Communication(s)

Authors

1 Professor, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

2 Assistant Professor, Cardiology Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Clinical Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 Assistant Professor, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

4 Professor, Physiology Research Center AND Department of Physiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Background: Opium addiction is a global problem which has implicated many societies. Opium addiction and drug abuse is related to harmful consequences which affect life style, biochemical factors, and vitamins values, and also is considered as a risk for heart diseases. Folate and B12 levels are related to homocysteine and studies about their levels in opium addicts are controversial; therefore, we designed this study to evaluate B12 and folate values in opium addicts. Methods: From the Kerman Coronary Artery Disease Risk Study (KERCADRS) which is a population-based study, we randomly selected 340 men and entered them into two groups: case (n = 170) and control group (n = 170). Then vitamin B12 and folate levels were measured. Findings: Opium addiction did not change B12 and folate levels significantly in opium addicts compared to non-addict control subjects. However, only some variables including blood pressure (BP) and diabetes positively and cigarette smoking, triglyceride (TG), alcohol, and cardiovascular disease (CVD) history negatively affected folate, and none of clinical and demographic variables influenced the B12 levels (P > 0.050). TG had significant effects on B12 and folate levels although opium addiction did not show any impact. Conclusion: High TG levels were accompanied by low levels of B12 and folate. Reduced B12 and folate values are accompanied by serum homocysteine elevation. As TG elevates in opium addicts, it can be considered as an important factor which affects vitamins levels and reduces their absorption. Opium addiction elevates homocysteine level, since we can conclude that homocysteine elevation in opium addicts is independent of B12 and folate levels

Keywords

1. United National Office on Drag and Crime. World drug report 2010 [Online]. [cited 2010]; Available from: URL: https://www.unodc.org/unodc/en/data-and-analysis/WDR-2010.html
2. Najafipour H, Masoomi M, Shahesmaeili A, Haghdoost AA, Afshari M, Nasri HR, et al. Effects of opium consumption on coronary artery disease risk factors and oral health: Results of Kerman Coronary Artery Disease Risk factors Study a population-based survey on 5900 subjects aged 15-75 years. Int J Prev Med 2015; 6: 42.
3. Nabipour S, Ayu Said M, Hussain Habil M. Burden and nutritional deficiencies in opiate addiction- systematic review article. Iran J Public Health 2014; 43(8): 1022-32.
4. Nazrul Islam SK, Jahangir Hossain K, Ahmed A, Ahsan M. Nutritional status of drug addicts undergoing detoxification: Prevalence of malnutrition and influence of illicit drugs and lifestyle. Br J Nutr 2002; 88(5): 507-13.
5. Cunningham PM. The use of sobriety nutritional therapy in the treatment of opioid addiction. J Addict Res Ther 2016; 7: 282.
6. Ghane T, Zamani N, Hassanian-Moghaddam H, Beyrami A, Noroozi A. Lead poisoning outbreak among opium users in the Islamic Republic of Iran, 2016-2017. Bull World Health Organ 2018; 96(3): 165-72.
7. Morabia A, Fabre J, Chee E, Zeger S, Orsat E, Robert A. Diet and opiate addiction: A quantitative assessment of the diet of non-institutionalized opiate addicts. Br J Addict 1989; 84(2): 173-80.
8. Masoomi M, Azdaki N, Shahouzehi B. Elevated plasma homocysteine concentration in opium-addicted individuals. Addict Health 2015; 7(3-4): 149-56.
9. Najafi M, Sheikhvatan M. Plausible impact of dietary habits on reduced blood sugar in diabetic opium addicts with coronary artery disease. Int Cardiovasc Res J 2012; 6(3): 75-8.
10. Estevez JF, Estevez FD, Calzadilla CH, Rodriguez EM, Romero CD, Serra-Majem L. Biochemical and haematological differentiation of opiate addicts from healthy subjects. A case control study. J Appl Biomed 2005; 3: 37-46.
11. Diaz-Flores Estevez JF, Diaz-Flores EF, Hernandez CC, Rodriguez Rodriguez EM, Diaz RC, Serra-Majem L. Application of linear discriminant analysis to the biochemical and haematological differentiation of opiate addicts from healthy subjects: A case-control study. Eur J Clin Nutr 2004; 58(3): 449-55.
12. Masoomi M, Ramezani MA, Karimzadeh H. The relationship of opium addiction with coronary artery
disease. Int J Prev Med 2010; 1(3): 182-6.
13. Ebrahimi M, Kazemi-Bajestani SM, Ghayour-Mobarhan M, Ferns GA. Coronary artery disease and its risk factors status in Iran: A review. Iran Red Crescent Med J 2011; 13(9): 610-23.
14. Shane B. Folate and vitamin B12 metabolism: Overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food Nutr Bull 2008; 29(2 Suppl): S5-16.
15. McEligot AJ, Rock CL, Gilpin EA, Pierce JP. Responsiveness of homocysteine concentrations to food and supplemental folate intakes in smokers and never-smokers enrolled in a diet intervention trial. Nicotine Tob Res 2006; 8(1): 57-66.
16. Gauthier GM, Keevil JG, McBride PE. The association of homocysteine and coronary artery disease. Clin Cardiol 2003; 26(12): 563-8.
17. Nusier MK, El-Dwairi A. Effects of vitamin B12 and folic acid on hyperhomocysteinemia in patients with acute myocardial infarction. J Health Sci 2007; 53(1): 16-22.
18. Jacobsen DW. Homocysteine and vitamins in cardiovascular disease. Clin Chem 1998; 44(8 Pt 2): 1833-43.
19. Masoomi M, Bahrampour A, Mireskandri M, Nematolahi A. Plasma homocysteine concentrations in young patients with acute myocardial infarction. ARYA Atheroscler 2007; 2(4): 193-6.
20. Najafipour H, Afshari M, Rostamzadeh F. Prevalence of multiple coronary artery disease risk factors in Kerman: A population-based study in southeast Iran. Iran J Med Sci 2018; 43(2): 140-9.
21. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association; 2000.
22. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006; 354(15): 1567-77.
23. Taylor BV, Oudit GY, Evans M. Homocysteine, vitamins, and coronary artery disease. Comprehensive review of the literature. Can Fam Physician 2000; 46: 2236-45.
24. Afarinesh MR, Haghpanah T, Divsalar K, Dehyadegary E, Shaikh-Aleslami A, Mahmoodi M. Changes in serum biochemical factors associated with opium addiction after addiction desertion. Addict Health 2014; 6(3-4): 138-45.
25. Shahouzehi B, Shokoohi M, Najafipour H. The effect of opium addiction on serum adiponectin and leptin levels in male subjects: A case control study from Kerman Coronary Artery Disease Risk Factors