Background: The present study aimed at investigating the role of depression and attachment styles in predicting cell phone addiction. Methods: In this descriptive correlational study, a sample including 100 students of Payame Noor University (PNU), Reyneh Center, Iran, in the academic year of 2013-2014 was selected using volunteer sampling. Participants were asked to complete the adult attachment inventory (AAI), Beck depression inventory-13 (BDI-13) and the cell phone overuse scale (COS). Findings: Results of the stepwise multiple regression analysis showed that depression and avoidant attachment style were the best predictors of students’ cell phone addiction (R2 = 0.23). Conclusion: The results of this study highlighted the predictive value of depression and avoidant attachment style concerning students’ cell phone addiction.