Background: Addiction as a biopsychosocial problem has been dramatically increased in our country. Adverse consequences of the addiction in women have been shown to be more than men, which in turn can affect family members’ health and wellbeing. The current study examined the efficacy of stress coping skills training in addicted women referring to an outpatient centre of addiction prevention located in Welfare Organization of Gorgan, Iran. Methods: 30 women with low levels of social adjustment measured by Social Adjustment Scale were randomly assigned to coping skills training with detoxification treatments (experimental) or detoxification alone groups. Both groups (N = 15) completed pre-post assessments of Bell’s adjustment Inventory. Experimental group received coping skills training program in ten sessions, each session last 90 minutes. Findings: Social adjustment was considerably improved more in addicted women who followed coping skills training program with detoxification treatment in comparison with the women who was undergone only detoxification treatment.Conclusion: Skills training program can help addicted women to better cope with their adjustment problem and these skills should be integrated into detoxification programs for this population.Keywords: Addiction, Detoxification, Stress, Coping skills training, Social adjustment.