ENT Department, Queen Elizabeth University Hospital, Glasgow, G51 4TF
10.22122/AHJ.2022.196452.1287
Abstract
Background: The use of opioids is considered a risk factor for laryngeal cancer. A retrospective study was performed to explore the relationship between recreational drug exposure and laryngeal cancer.
Methods: Patients diagnosed between the 1st of January 2013 and the 31st of December 2017 using ICD-10 CD-32 coding were identified from the Head and Neck Multidisciplinary Team database. We divided the study population into two cohorts (RD and non-RD) and compared the demographics, morbidity, and outcomes of these two populations. In addition, we performed case-matched analysis to control for potential confounding factors including gender, alcohol use and cigarette smoking.
Findings: 329 patients in Glasgow, Scotland were included with a mean age of 64.96 ± 10.94 and a follow-up of 24 ± 13.91 months. Of these, 39 reported recreational drug use (RD). RD was associated with younger age (53.0 vs. 66.6, p<0.001) at diagnosis with laryngeal cancer. A greater proportion of tumours occurred in the supraglottic subsite (p=0.041). Furthermore, these patients were more likely to undergo tracheostomy (RR=2.50, 95% CI: 1.41-4.44, p=0.008) and laryngectomy (RR=2.25, 95% CI: 1.57-3.21, p<0.001). Recreational drug users were more likely to require enteral feeding support (RR= 1.44, 95% CI: 1.13-1.84, p=0.02) during oncological treatment. No survival differences were noted at 1, 2, or 3-years (plog-rank=0.83). Case matched analysis correcting for smoking, alcohol and gender confirmed that recreational drug users were younger at diagnosis with a predilection for the supraglottic subsite.
Conclusion: Recreational drug use is associated with an increased burden of disease and morbidity in laryngeal cancer. We suggest that clinicians view recreational drug exposure as a red flag in those with suspected laryngeal cancer regardless of patient age.
Woodley, N., Mohd Slim, M. A., Ton, T., Montgomery, J., & Douglas, C. (2022). Does recreational drug use influence survival and morbidity associated with laryngeal cancer. Addiction & Health, 14(2), 115-26. doi: 10.22122/AHJ.2022.196452.1287
MLA
Niall Woodley; Mohd Afiq Mohd Slim; Trung Ton; Jenny Montgomery; Catriona Douglas. "Does recreational drug use influence survival and morbidity associated with laryngeal cancer". Addiction & Health, 14, 2, 2022, 115-26. doi: 10.22122/AHJ.2022.196452.1287
HARVARD
Woodley, N., Mohd Slim, M. A., Ton, T., Montgomery, J., Douglas, C. (2022). 'Does recreational drug use influence survival and morbidity associated with laryngeal cancer', Addiction & Health, 14(2), pp. 115-26. doi: 10.22122/AHJ.2022.196452.1287
VANCOUVER
Woodley, N., Mohd Slim, M. A., Ton, T., Montgomery, J., Douglas, C. Does recreational drug use influence survival and morbidity associated with laryngeal cancer. Addiction & Health, 2022; 14(2): 115-26. doi: 10.22122/AHJ.2022.196452.1287
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