Zhu H, Zhou W. Discharge activities of neurons in
the nucleus paragigantocellularis during the
development of morphine tolerance and dependence:
A single unit study in chronically implanted rats. Eur
J Pharmacol 2010; 636(1-3): 65-72.
2. Wang X, Loram LC, Ramos K, de Jesus AJ, Thomas
J, Cheng K, et al. Morphine activates
neuroinflammation in a manner parallel to
endotoxin. Proc Natl Acad Sci USA 2012; 109(16):
6325-30.
3. DeLeo JA, Tanga FY, Tawfik VL. Neuroimmune
activation and neuroinflammation in chronic pain
and opioid tolerance/hyperalgesia. Neuroscientist
2004; 10(1): 40-52.
4. Bachstetter AD, Van Eldik LJ. The p38 MAP kinase
family as regulators of proinflammatory cytokine
production in degenerative diseases of the CNS.
Aging Dis 2010; 1(3): 199-211.
5. Hutchinson MR, Coats BD, Lewis SS, Zhang Y,
Sprunger DB, Rezvani N, et al. Proinflammatory
cytokines oppose opioid-induced acute and chronic
analgesia. Brain Behav Immun 2008; 22(8): 1178-89.
6. Horvath RJ, Landry RP, Romero-Sandoval EA,
DeLeo JA. Morphine tolerance attenuates the
resolution of postoperative pain and enhances spinal
microglial p38 and extracellular receptor kinase
phosphorylation. Neuroscience 2010; 169(2): 843-54.
7. Song P, Zhao ZQ. The involvement of glial cells in
the development of morphine tolerance. Neurosci
Res 2001; 39(3): 281-6.
8. Ridet JL, Malhotra SK, Privat A, Gage FH. Reactive
astrocytes: cellular and molecular cues to biological
function. Trends Neurosci 1997; 20(12): 570-7.
9. Middeldorp J, Hol EM. GFAP in health and disease.
Prog Neurobiol 2011; 93(3): 421-43.
10. Esmaeili-Mahani S, Ebrahimi B, Abbasnejad M,
Rasoulian B, Sheibani V. Satureja khuzestanica
prevents the development of morphine analgesic
tolerance through suppression of spinal glial cell
activation in rats. J Nat Med 2015; 69(2): 165-70.
11. Ward J, Rosenbaum C, Hernon C, McCurdy CR,
Boyer EW. Herbal medicines for the management of
opioid addiction: Safe and effective alternatives to
conventional pharmacotherapy? CNS Drugs 2011;
25(12): 999-1007.
12. Afzal M, Al-Hadidi D, Menon M, Pesek J, Dhami
MS. Ginger: An ethnomedical, chemical and
pharmacological review. Drug Metabol Drug
Interact 2001; 18(3-4): 159-90.
13. Rasmussen P. Ginger--Zingiber officinale Roscoe,
Zingiberaceae. J Prim Health Care 2011; 3(3): 235-6.
14. Rahmani AH, Shabrmi FM, Aly SM. Active
ingredients of ginger as potential candidates in the
prevention and treatment of diseases via modulation
of biological activities. Int J Physiol Pathophysiol
Pharmacol 2014; 6(2): 125-36.
15. Wohlmuth H Phytochemistry and pharmacology of
plants from the ginger family, Zingiberaceae [PhD
Thesis]. Lismore, NSW, Australia: Southern Cross
University; 2008.
16. Ali BH, Blunden G, Tanira MO, Nemmar A. Some
phytochemical, pharmacological and toxicological
properties of ginger (Zingiber officinale Roscoe): A
review of recent research. Food Chem Toxicol 2008;
46(2): 409-20.
17. Grzanna R, Lindmark L, Frondoza CG. Ginger--an
herbal medicinal product with broad antiinflammatory actions. J Med Food 2005; 8(2): 125-32.
18. Torkzadeh-Mahani S, Nasri S, Esmaeili-Mahani S.
Ginger (zingiber officinale roscoe) prevents
?????????? Torkzadeh-Mahani et al.
Addict Health, Spring 2019; Vol 11 , No 2 71
http://ahj.kmu.ac.ir, 04 April
morphine-induced addictive behaviors in conditioned
place preference test in rats. Addict Health 2014;
6(1-2): 65-72.
19. Milligan ED, Watkins LR. Pathological and
protective roles of glia in chronic pain. Nat Rev
Neurosci 2009; 10(1): 23-36.
20. Lazriev IL, Kiknadze GI, Kutateladze II, Nebieridze
MI. Effect of morphine on the number and branching
of astrocytes in various regions of rat brain. Bull Exp
Biol Med 2001; 131(3): 248-50.
21. Schwarz JM, Hutchinson MR, Bilbo SD. Early-life
experience decreases drug-induced reinstatement of
morphine CPP in adulthood via microglial-specific
epigenetic programming of anti-inflammatory IL-10
expression. J Neurosci 2011; 31(49): 17835-47.
22. Cooper ZD, Jones JD, Comer SD. Glial modulators:
A novel pharmacological approach to altering the
behavioral effects of abused substances. Expert Opin
Investig Drugs 2012; 21(2): 169-78.
23. Choi DK, Koppula S, Suk K. Inhibitors of microglial
neurotoxicity: Focus on natural products. Molecules
2011; 16(2): 1021-43.
24. Dedov VN, Tran VH, Duke CC, Connor M, Christie
MJ, Mandadi S, et al. Gingerols: A novel class of
vanilloid receptor (VR1) agonists. Br J Pharmacol
2002; 137(6): 793-8.
25. Svensson CI, Marsala M, Westerlund A, Calcutt NA,
Campana WM, Freshwater JD, et al. Activation of
p38 mitogen-activated protein kinase in spinal
microglia is a critical link in inflammation-induced
spinal pain processing. J Neurochem 2003; 86(6):
1534-44.
26. Cui Y, Chen Y, Zhi JL, Guo RX, Feng JQ, Chen PX.
Activation of p38 mitogen-activated protein kinase
in spinal microglia mediates morphine
antinociceptive tolerance. Brain Res 2006; 1069(1):
235-43.
27. Jung HW, Yoon CH, Park KM, Han HS, Park YK.
Hexane fraction of Zingiberis Rhizoma Crudus
extract inhibits the production of nitric oxide and
proinflammatory cytokines in LPS-stimulated BV2
microglial cells via the NF-kappaB pathway. Food
Chem Toxicol 2009; 47(6): 1190-7.
28. Wang Z, Ma W, Chabot JG, Quirion R. Cell-type
specific activation of p38 and ERK mediates
calcitonin gene-related peptide involvement in
tolerance to morphine-induced analgesia. FASEB J
2009; 23(8): 2576-86.
29. Watkins LR, Hutchinson MR, Rice KC, Maier SF.
The "toll" of opioid-induced glial activation:
improving the clinical efficacy of opioids by
targeting glia. Trends Pharmacol Sci 2009; 30(11):
581-91.
30. Horvath RJ, DeLeo JA. Morphine enhances
microglial migration through modulation of P2X4
receptor signaling. J Neurosci 2009; 29(4):
998-1005.
31. Raghavendra V, Tanga FY, DeLeo JA. Attenuation
of morphine tolerance, withdrawal-induced
hyperalgesia, and associated spinal inflammatory
immune responses by propentofylline in rats.
Neuropsychopharmacology 2004; 29(2): 327-34.