TY - JOUR ID - 84650 TI - Assessment of Cognitive Functions in Methadone Maintenance Patients JO - Addiction and Health JA - AHJ LA - en SN - 2008-4633 AU - Mazhari, Shahrzad AU - Keshvari, Zeinab AU - Sabahi, Abdolreza AU - Mottaghian, Shirin AD - Associate Professor, Neuroscience Research Center, Institute of Neuropharmachology AND ‎Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, ‎Kerman, Iran AD - ‎Resident, Department of Psychiatry, School of Medicine, Kerman University of Medical ‎Sciences, Kerman, Iran‎ AD - ‎Assistant Professor, Department of Psychiatry, School of Medicine, Kerman University of ‎Medical Sciences, Kerman, Iran AD - ‎General Practitioner, School of Medicine, Kerman University of Medical Sciences, Kerman, ‎Iran Y1 - 2015 PY - 2015 VL - 7 IS - 3-4 SP - 109 EP - 116 KW - Methadone maintenance KW - opiates KW - Cognitive dysfunction DO - N2 - Background: Methadone maintenance has received little scientific attention regarding neurocognitive effects. This study is aimed to assess the neuropsychological performance of methadone maintenance patients (MMP) compared to those healthy controls. Methods: Thirty-five MMP and 35 healthy controls, matched for age, gender, education and employment status, examined on a battery of tests aimed at assessing verbal fluency, executive functions, verbal memory, and working memory, using controlled oral word association test (COWAT), trial making test (TMT) Part A and B, Rey auditory verbal learning test (RAVLT), and backward digit span. Findings: MMP performed significantly poorly than controls in cognitive domains of verbal fluency, executive function, and verbal memory. MMP did not exhibit impairment in working memory, and TMT Part A compared to controls. Conclusion: These results suggest that methadone consumption induces significant cognitive impairment that could compromise drug-treatment outcomes in MMP. UR - https://ahj.kmu.ac.ir/article_84650.html L1 - https://ahj.kmu.ac.ir/article_84650_c82e6a7c20e06637690b13f3a89d024a.pdf ER -