@article { author = {Woodley, Niall and Mohd Slim, Mohd Afiq and Ton, Trung and Montgomery, Jenny and Douglas, Catriona}, title = {Does recreational drug use influence survival and morbidity associated with laryngeal cancer}, journal = {Addiction and Health}, volume = {14}, number = {2}, pages = {115-26}, year = {2022}, publisher = {Kerman University of Medical Sciences}, issn = {2008-4633}, eissn = {2008-8469}, doi = {10.22122/AHJ.2022.196452.1287}, abstract = {Background: The use of opioids is considered a risk factor for laryngeal cancer. A retrospective study was performed to explore the relationship between recreational drug exposure and laryngeal cancer.Methods: Patients diagnosed between the 1st of January 2013 and the 31st of December 2017 using ICD-10 CD-32 coding were identified from the Head and Neck Multidisciplinary Team database. We divided the study population into two cohorts (RD and non-RD) and compared the demographics, morbidity, and outcomes of these two populations. In addition, we performed case-matched analysis to control for potential confounding factors including gender, alcohol use and cigarette smoking.Findings: 329 patients in Glasgow, Scotland were included with a mean age of 64.96 ± 10.94 and a follow-up of 24 ± 13.91 months. Of these, 39 reported recreational drug use (RD). RD was associated with younger age (53.0 vs. 66.6, p<0.001) at diagnosis with laryngeal cancer. A greater proportion of tumours occurred in the supraglottic subsite (p=0.041). Furthermore, these patients were more likely to undergo tracheostomy (RR=2.50, 95% CI: 1.41-4.44, p=0.008) and laryngectomy (RR=2.25, 95% CI: 1.57-3.21, p<0.001). Recreational drug users were more likely to require enteral feeding support (RR= 1.44, 95% CI: 1.13-1.84, p=0.02) during oncological treatment. No survival differences were noted at 1, 2, or 3-years (plog-rank=0.83). Case matched analysis correcting for smoking, alcohol and gender confirmed that recreational drug users were younger at diagnosis with a predilection for the supraglottic subsite.Conclusion: Recreational drug use is associated with an increased burden of disease and morbidity in laryngeal cancer. We suggest that clinicians view recreational drug exposure as a red flag in those with suspected laryngeal cancer regardless of patient age.}, keywords = {Head and Neck neoplasms,Laryngeal neoplasms,Substance-related disorders,Analgesics, Opioid, Illicit drugs}, url = {https://ahj.kmu.ac.ir/article_91996.html}, eprint = {https://ahj.kmu.ac.ir/article_91996_f7fcc23444b1a74e6ae7c572722c252a.pdf} }