@article { author = {Torkzadeh-Mahani, Shima and Nasri, Sima and Esmaeili-Mahani, Saeed}, title = {Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats}, journal = {Addiction and Health}, volume = {6}, number = {1-2}, pages = {65-72}, year = {2014}, publisher = {Kerman University of Medical Sciences}, issn = {2008-4633}, eissn = {2008-8469}, doi = {}, abstract = {Background: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-oxidative and antinociceptive properties. However, its influences on morphine-induced addictive behaviors have not yet been clarified. Methods: For conditioning to the morphine, the male Wistar rats received morphine (12 mg/kg intraperitoneally or i.p.) for 6 consecutive days and treatment groups were given different doses of ginger (25, 50 and 100 mg/kg intragastrically or i.g.) 30 min before morphine injection. For investigating addictive seeking behavior, conditioned place preference test (CPP) was used. Findings: Our result demonstrated that injection of morphine for 6 days induces dependency to morphine and creates addictive seeking behavior and ginger (100 mg/kg) could decrease time spend in conditioning box (addictive seeking behavior). Conclusion: The data indicated that ginger extract has a potential anti-addictive property against chronic usage of morphine.}, keywords = {Ginger extract,Morphine,Conditioned place preference,Addictive seeking behavior,Rats}, url = {https://ahj.kmu.ac.ir/article_84617.html}, eprint = {https://ahj.kmu.ac.ir/article_84617_e016a94a0dcb915e580f32defd07094e.pdf} }