1
Department of Cellular and Molecular biology, Bonab Branch, Islamic Azad University, Bonab, Iran
2
Department of Genetics, Bonab Branch, Islamic Azad University, Tabriz, Iran
Abstract
Background: In addition to its physical and psychological effects on consumers, addiction is one of the world's most significant personal and social problems, endangering the sociocultural, political, and societal health. Important roles are played by genetic factors in susceptibility to methamphetamine dependence. This study aimed to examine the relationship between the rs2652511 polymorphism in the promoter region of the SLC6A3 gene and methamphetamine use disorder in Iranian males.
Methods: In this case-control study, we recruited 100 men with methamphetamine use disorder as cases and 100 age- and ethnically-matched normal men from East Azerbaijan, Tabriz, Iran as healthy controls. From peripheral blood leukocytes, genomic DNA was extracted. PCR-RFLP was utilized for genotyping.
Results: The genotype distribution of rs2652511 polymorphism in case group was 56% CC, 33% CT, and 11% 44, whereas in controls group was 25% CC, 42% CT, and 33% TT. Statistical analysis showed that the genotype and allele frequencies of rs2652511 polymorphism were significantly different between patients and healthy controls (p>0.05).
Conclusion: Our research revealed that the rs2652511 polymorphism in the SLC6A3 gene was associated with methamphetamine misuse disorder in the Iranian population. To determine the precise function of this polymorphism in the pathology of methamphetamine use disorder, however, more research is needed on various racial and geographical groups.
Aminzadeh Khosroshahi, M., Farrokhi, A., & Soltanzadeh, H. (2024). Association SLC6A3 gene rs2652511 polymorphism with methamphetamine abuse disorder in Iranian population. Addiction & Health, (), -.
MLA
Mohaddeseh Aminzadeh Khosroshahi; Ali Farrokhi; Hossein Soltanzadeh. "Association SLC6A3 gene rs2652511 polymorphism with methamphetamine abuse disorder in Iranian population". Addiction & Health, , , 2024, -.
HARVARD
Aminzadeh Khosroshahi, M., Farrokhi, A., Soltanzadeh, H. (2024). 'Association SLC6A3 gene rs2652511 polymorphism with methamphetamine abuse disorder in Iranian population', Addiction & Health, (), pp. -.
VANCOUVER
Aminzadeh Khosroshahi, M., Farrokhi, A., Soltanzadeh, H. Association SLC6A3 gene rs2652511 polymorphism with methamphetamine abuse disorder in Iranian population. Addiction & Health, 2024; (): -.
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