Waterpipe tobacco components and their association with oxidative stress

Document Type : Review Article(s)

Authors

1 Tobacco and Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

2 Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

3 Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Abstract

Oxidative stress (OS) is the result of imbalance between the formation and detoxification of reactive species (RS). Although RS at low or moderate levels play numerous physiological roles, high concentrations can lead to disturbances in signaling and metabolic pathways and cause different metabolic, chronic, and age-related disorders. Several endogenous and exogenous processes may lead to the RS formation. The severity of oxidative stress can be reduced with the help of antioxidants. Tobacco is one of the most important environmental factors which contributes to RS production. After cigarette smoking, water-pipe tobacco smoking (WTS) is ranked the second popular tobacco product. Its popularity is growing rapidly due to flavored products, social acceptability and so on. However, studies have shown that WTS is associated with increased risk of arterial stiffness, ischemic heart disease and several cancer types. In this study, we aimed to review the most recent evidence on WTS constituents and their association with oxidative stress.

Keywords