Methadone Replacement Therapy and Sexual Disorders among Opium Dependent Iranian Men: A Meta-Analysis Study

Masoudeh Babakhanian, Ali Akbar Haghdoost, Mahdi Afshari, Fatemeh Taghizadeh, Mahmood Moosazadeh

Abstract


Background: Evaluation of sexual disorders among persons receiving methadone replacement therapy is of great importance, because these problems may lead to non-compliance and relapse. This study aimed to estimate the effect of methadone maintenance therapy (MMT) on sexual function among addicted Iranian men using met-analysis.

Methods: Investigating the available data banks, relevant studies were identified. After exclusion of duplicates, irrelevant papers and low quality articles, eligible papers were entered into the meta-analysis. Prevalence and standardized mean difference of sexual function scores were illustrated by forest plots based on sexual desire, orgasm and erectile function.

Findings: During the primary search, 5341 evidences were identified. After application of the inclusion/exclusion criteria and quality assessment, nine papers were detected eligible for final meta-analysis. Total prevalence [95% confidence intervals (CI)] of sexual disorders and erectile dysfunction among Iranian men under methadone therapy were estimated as 66.3% (27.1-105.5) and 77.5% (61.9-93.1), respectively. The standardized mean differences (95% CI) of Sexual desire, orgasm and erection before and after methadone therapy were estimated as 0.16 (-0.68, 0.99), -0.01 (-0.75, 0.74) and 0.11 (-0.41, 0.64), respectively.

Conclusion: This meta-analysis showed that methadone therapy did not significantly influence the sexual desire, erectile function and orgasm among opium dependent men.


Keywords


Methadone therapy; Sexual dysfunction; Libido; Orgasm; Erection

Full Text:

PDF

References


Chekuri V, Gerber D, Brodie A, Krishnadas R. Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. Addict Behav 2012; 37(1): 124-6.

Shiri R, Falah Hassani K, Ansari M. Association between opium abuse and comorbidity in diabetic men. Am J Addict 2006; 15(6): 468-72.

Chen W, Li X, Li X, Ling L, Xia Y, Chen J, et al. Erectile dysfunction among male heroin addicts receiving methadone maintenance treatment in Guangdong, China. J Addict Med 2012; 6(3): 212-8.

Babakhanian M, Alam Mehrjerdi Z, Shenaiy Y. Sexual dysfunction in male crystalline heroin dependents before and after MMT: A pilot study. Arch Iran Med 2012; 15(12): 751-5.

Tatari F, Shakeri J, Farnia V, Heidari F, Rezaei M. Bupropion in methadone induced erectile dysfunction. Life Sci J 2013; 10(9): 330-2.

Parvaresh N, Sabahi AR, Mazhari S, Gilani H. A study of the sexual function, sleep, and weight status of patients after 6 months of methadone maintenance treatment. Addict Health 2015; 7(1-2): 24-9.

Hosseini SH, Isapour A, Tavakoli M, Taghipour M, Rasuli M. Erectile dysfunction in methadone maintenance patients: a cross sectional study in northern Iran. Iran J Psychiatry 2013; 8(4): 172-8.

Kheirabadi GR, Salehi M, Golafshan N, Maracy MR. Sexual dysfunction of men on methadone maintenance treatment mmt and its, relation with methadone dose and blood level of testosterone and prolactine. Med J Tabriz Univ Med Sci 2012; 34(4): 16. [In Persian].

Kheradmand A, Amini Ranjbar Z, Zeynali Z, Sabahy AR, Nakhaee N. Sleep quality and sexual function in patients under methadone maintenance treatment. Int J High Risk Behav Addict 2015; 4(4): e23550.

Hanbury R, Cohen M, Stimmel B. Adequacy of sexual performance in men maintained on methadone. Am J Drug Alcohol Abuse 1977; 4(1): 13-20.

Risen CB. A guide to taking a sexual history. Psychiatr Clin North Am 1995; 18(1): 39-53.

Johnson MW, Bruner NR. Test-retest reliability and gender differences in the sexual discounting task among cocaine-dependent individuals. Exp Clin Psychopharmacol 2013; 21(4): 277-86.

McCabe MP, Sharlip ID, Atalla E, Balon R, Fisher AD, Laumann E, et al. Definitions of sexual dysfunctions in women and men: A consensus statement from the fourth international consultation on sexual medicine 2015. J Sex Med 2016; 13(2): 135-43.

Waldinger MD, Schweitzer DH. Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part I--validity of DSM-IV-TR. J Sex Med 2006; 3(4): 682-92.

Hallinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia J. Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment. J Sex Med 2008; 5(3): 684-92.

Langrod J, Lowinson J, Ruiz P. Methadone treatment and physical complaints: A clinical analysis. Int J Addict 1981; 16(5): 947-52.

Moosazadeh M. Meta-Analysis of Prevalence of Smoking in 15-64-year-old Population of West of Iran. Int J Prev Med 2013; 4(10): 1108-14.

Moosazadeh M, Nekoei-Moghadam M, Aliram-Zany M, Amiresmaili M. Identification of mutation of glucose-6-phosphate dehy-drogenase (G6PD) in Iran: Meta- analysis study. Iran J Public Health 2013; 42(9): 1007-15.

Moosazadeh M, Amiresmaili M, Aliramezany M. Prevalence of G6PD deficiency in Iran, a mata-analysis. Acta Med Iran 2014; 52(4): 256-64.

von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Prev Med 2007; 45(4): 247-51.

Rahbar Taramsari M, Badsar A, Falahatkar S, Movassagh H, Fallah KarKan M, Montazeri S, et al. The Possible Effects of Methadone Maintenance Therapy on Erectile Dysfunction in Male Addicts Visiting MMT Centers of Rasht. Iran J Toxicol 2014; 8(25): 1081-5. [In Persian].

Roshanpajhu M, Khodaei MR, Taafi E, Rezaei O, Nazeri-Astaneh A, Baghestani AR, et al. The Effect of Methadone on Sexual Function in Male Dependent to Opiates. J Rehab 2012; 12: 65-71. [In Persian].

Tatari F, Farnia V, Nasiri RF, Najafi F. Trazodone in methandone induced erectile dysfunction. Iran J Psychiatry 2010; 5(4): 164-6.

Goldsmith D, Hunt D, Lipton D, Strug D. Methadone folklore: Beliefs about side effects and their impact on treatment. Human Organization 1984; 43(3): 330-40.

Yee A, Loh HS, Hisham Hashim HM, Ng CG. The prevalence of sexual dysfunction among male patients on methadone and buprenorphine treatments: A meta-analysis study. J Sex Med 2014; 11(1): 22-32.

Trajanovska AS, Vujovic V, Ignjatova L, Janicevic-Ivanovska D, Cibisev A. Sexual dysfunction as a side effect of hyperprolactinemia in methadone maintenance therapy. Med Arch 2013; 67(1): 48-50.

Nik Ruzyanei NJ, Noormazita M, Azlin B, Normala I, Hazli Z, Abdul Aziz S, et al. Clinical correlates of erectile dysfunction among male patients on methadone maintenance therapy (MMT) in Kuala Lumpur. Malaysian Journal of Medicine and Health Sciences 2012; 8(1): 27-35.

Hamidi Madani A, Ghanbari A, Fallah Manshadi L, Emadi SA. Survey the frequency of risk factors in men with erectile dysfunction. J Guilan Univ Med Sci 2010; 19(75): 36-45. [In Persian].

Cicero TJ, Bell RD, Wiest WG, Allison JH, Polakoski K, Robins E. Function of the male sex organs in heroin and methadone users. N Engl J Med 1975; 292(17): 882-7.




DOI: http://dx.doi.org/10.22122/ahj.v9i1.400

Refbacks

  • There are currently no refbacks.