Loperamide Dependence: A Case Report

Mehran Zarghami, Maryam Rezapour

Abstract


Background: Loperamide is used as an antidiarrheal drug and is available over-the-counter. It cannot pass the blood-brain barrier and it does not have a considerable abuse potential. It can lead to dangerous cardiac arrhythmia.

Case Report: Herein, we report a 35-year-old man with a 13-year history of abusing opioids who had undergone detoxification for four times during this period. He underwent detoxification for using 200 mg loperamide daily with anticholinergic agents, clonidine, non-steroidal analgesics, and diazepam. No evidence of arrhythmia was seen in the patient.

Conclusion: Tolerating high doses of loperamide could be dangerous and increases the risk of fatal cardiac arrhythmias.


Keywords


Loperamide; Addiction; Cardiac arrhythmia

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References


Spinner HL, Lonardo NW, Mulamalla R, Stehlik J. Ventricular tachycardia associated with high-dose chronic loperamide use. Pharmacotherapy 2015; 35(2): 234-8.

Regnard C, Twycross R, Mihalyo M, Wilcock A. Loperamide. J Pain Symptom Manage 2011; 42(2): 319-23.

Lexicomp Online. Loperamide Hydrochloride Oral-Facts and Comparisons eAnswers [online]. [cited 2014 Jul]; Available from: URL: http://qnf.qa/lco/action/doc/retrieve/docid/fc_dfc/5549583

Friedli G, Haenggeli CA. Loperamide overdose managed by naloxone. Lancet 1980; 1(8183): 1413.

Marraffa JM, Holland MG, Sullivan RW, Morgan BW, Oakes JA, Wiegand TJ, et al. Cardiac conduction disturbance after loperamide abuse. Clin Toxicol (Phila) 2014; 52(9): 952-7.

Drugs. Loperamide dosage [Online]. [cited 2015 Mar 31]; Available from: URL: https://www.drugs.com/dosage/loperamide.html

Drug Forum. Recommended loperamide dosage for withdrawal? [Online]. [cited 2015 Mar 31]; Available from: URL: https://drugs-forum.com/threads/recommended-loperamide-dosage-for-withdrawal.172179/

Daniulaityte R, Carlson R, Falck R, Cameron D, Perera S, Chen L, et al. "I just wanted to tell you that loperamide WILL WORK": a web-based study of extra-medical use of loperamide. Drug Alcohol Depend 2013; 130(1-3): 241-4.

Lavin MR. Misuse of loperamide in anxiety disorder patients. Depress Anxiety 1996; 4(5): 254-5.

Langlitz N, Schotte K, Bschor T. Loperamide abuse in anxiety disorder. Nervenarzt 2001; 72(7): 562-4. [In German].




DOI: http://dx.doi.org/10.22122/ahj.v9i1.399

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