Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats

Shima Torkzadeh-Mahani, Sima Nasri, Saeed Esmaeili-Mahani

Abstract


Background: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-oxidative and antinociceptive properties. However, its influences on morphine-induced addictive behaviors have not yet been clarified.

Methods: For conditioning to the morphine, the male Wistar rats received morphine (12 mg/kg intraperitoneally or i.p.) for 6 consecutive days and treatment groups were given different doses of ginger (25, 50 and 100 mg/kg intragastrically or i.g.) 30 min before morphine injection. For investigating addictive seeking behavior, conditioned place preference test (CPP) was used.

Findings: Our result demonstrated that injection of morphine for 6 days induces dependency to morphine and creates addictive seeking behavior and ginger (100 mg/kg) could decrease time spend in conditioning box (addictive seeking behavior).

Conclusion: The data indicated that ginger extract has a potential anti-addictive property against chronic usage of morphine.


Keywords


Ginger extract, Morphine, Conditioned place preference, Addictive seeking behavior, Rats

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DOI: http://dx.doi.org/10.22122/ahj.v6i1-2.183

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