Kerman University of Medical Sciences

Document Type : Original Article

Authors

1 2. Cardiovascular Research Center,Institute of Basic andClinical Physiology Sciences,Kerman University of Medical Sciences,Kerman,Iran

2 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences AND Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 1 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Introduction: Coronary artery ectasia (CAE) is a rare cardiovascular disorder with unknown mechanisms and related risk factors. The roles played by homocysteine in induction of cardiovascular diseases have also been documenetd previously. This project was designed to asses the relashenship between opium and coronary artery ectasia and Coronary artery disease (CAD) .

Material and methods: This cross-sectional study was performed on the 46 patients with CAE, 30 patients with coronary artery disease (CAD) and 42 cases without CAE and CAD (controls). Demographic data and information regarding opium consuming and also smoking were collected using standard chek list. Serum levels of homocysteine, creatinine (Cr), urea, fasting blood glucose (FBG), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and cholestrol (Chol) were determined.

Results: Statistical analysis revealed that opium consumers were significantly higher in CAD and CAE patients when compared to healthy controls. Opium increased serum levels of Cr in the normal controls, and decreased HDL in the CAD patients. Homocysteine serum levels were not altered among the groups.

Discussion: the results of study showed that opium addicition is assosiated with
Increased risk of Coronary artery ectasia and Coronary artery disease independent of homocysteine serum levels .

Keywords