Background: Today, increased use of methamphetamine in homosexual men is associated with high-risk sexual
behaviors and (HIV) epidemic. Mobile phone-based interventions are an accessible and rapid method to
provide healthcare services to this population. This study aimed to systematically review the effects of mobile
phone-based interventions on methamphetamine use and high-risk sexual behaviors in homosexual men.
Methods: This systematic review was conducted by two researchers via searching in PubMed, Google Scholar,
Web of Science, Scopus, and PsycINFO databases to retrieve the published articles regarding the effects of
mobile phone-based interventions on the control of methamphetamine use and high-risk sexual behaviors.
Findings: Among 250 unique articles that were retrieved, only five cases met all the inclusion criteria of the
study. Accordingly, some of the applied interventions included text messaging (n = 4) and mobile apps
(n = 1). In this regard, the use of text messaging significantly decreased the rates of methamphetamine use,
condomless anal intercourse (CAI), and HIV transmission among homosexual men.
Conclusion: According to the results, short-term interventions based on text messaging could decrease the
rates of methamphetamine use and the high-risk sexual behaviors associated with HIV infection in
homosexual men. Despite the positive impact of these interventions, long-term follow-ups are required for
individuals using methamphetamine in different communities