Investigating Changes in Serum Biochemical Parameters in Opium Addicts Before and During Addiction Treatment

Document Type : Original Article(s)

Authors

1 Resident, Neurosciences Research Center AND Department of Internal Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

2 Associate Professor, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

3 Researcher, Neurosciences Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

4 General Practitioner, Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

5 Student of Medicine, Infectious Disease and Tropical Research Center, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Background: Iran is one of the major consumers of opium and opiate substances in the world. Addiction has become a very important issue in the 21st century and an urgent one in Iran. The consumption of this substance leaves a variety of impacts on the human body. The goal of this study is to investigate the changes of the biochemical parameters derived from opiate substances in addicts during their treatment.Methods: This is a cross-sectional research that focused on 40 individuals dependent on the consumption of opium. Their blood samples were taken before and during treatment, and their fasting blood sugar (FBS), sodium, calcium, phosphorus, creatinine, urea, uric acid, total protein, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol were measured. Data were analyzed by SPSS using paired t-test.Findings: The results showed that serum uric acid, LDL, cholesterol, and the total protein levels significantly decreased during the treatment in comparison with the time before the treatment (P < 0.050). Yet, the serum fasting glucose, urea, creatinine, HDL, triglycerides, calcium, phosphorous, sodium, and potassium showed no significant change the time prior and during the treatment.Conclusion: Given the findings of the analysis, opium addiction has a number of destructive impacts on the lipid profile and uric acid. In addition, the level of total protein decreased during the treatment.

Keywords

References

  1. Singer M. Drugs and development: the global impact of drug use and trafficking on social and economic development. Int J Drug Policy 2008; 19(6): 467-78.
  2. Buchbauer G, Nikiforov A, Remberg B. Headspace constituents of opium. Planta Med 1994; 60(2): 181-3.
  3. Katzung BJ. Basic and clinical pharmacology. Trans. Fatullahi A, Khodaei M. Tehran, Iran: Arjmand Publications; 2007. p. 512-32. [In Persian].
  4. Molina PE, Hashiguchi Y, Ajmal M, Mazza M, Abumrad NN. Differential hemodynamic, metabolic and hormonal effects of morphine and morphine-6-glucuronide. Brain Res 1994; 664(1-2): 126-32.
  5. Ipp E, Schusdziarra V, Harris V, Unger RH. Morphine-induced hyperglycemia: role of insulin and glucagon. Endocrinology 1980; 107(2): 461-3.
  6. Shahouzehi B, Shokoohi M, Najafipour H. The effect of opium addiction on serum adiponectin and leptin levels in male subjects: a case control study from Kerman Coronary Artery Disease Risk Factors Study (KERCADRS). Excli J 2013; 12: 916-23.
  7. Bossone CA, Hannon JP. Metabolic actions of morphine in conscious chronically instrumented pigs. Am J Physiol 1991; 260(6 Pt 2): R1051-R1057.
  8. Masoudkabir F, Sarrafzadegan N, Eisenberg MJ. Effects of opium consumption on cardiometabolic diseases. Nat Rev Cardiol 2013; 10(12): 733-40.
  9. Najafipour H, Masoomi M, Shahesmaeili A, Haghdoost AA, Afshari M, Nasri HR, et al. Effects of opium consumption on coronary artery disease risk factors and oral health: Results of Kerman Coronary Artery Disease Risk factors Study a population-based survey on 5900 subjects aged 15-75 years. Int J Prev Med 2015; 6: 42.
  10. Asgary S, Sarrafzadegan N, Naderi GA, Rozbehani R. Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter? Lipids Health Dis 2008; 7: 42.
  11. Sumathi T, Niranjali Devaraj S. Effect of Bacopa monniera on liver and kidney toxicity in chronic use of opioids. Phytomedicine 2009; 16(10): 897-903.
  12. Afarinesh MR, Haghpanah T, Divsalar K, Dehyadegary E, Shaikh-Aleslami A, Mahmoodi M. Changes in serum biochemical factors associated with opium addiction after addiction desertion. Addict Health 2014; 6(3-4): 138-45.
  13. Divsalar K, Haghpanah T, Afarinesh M, Mahmoudi Zarandi M. Opium and heroin alter biochemical parameters of human's serum. Am J Drug Alcohol Abuse 2010; 36(3): 135-9.
  14. Bryant HU, Story JA, Yim GK. Morphine-induced alterations in plasma and tissue cholesterol levels. Life Sci 1987; 41(5): 545-54.
  15. Shahryari J, Poormorteza M, Noori-Sorkhani A, Divsalar K, Abbasi-Oshaghi E. The effect of concomitant ethanol and opium consumption on lipid profiles and atherosclerosis in golden Syrian hamster's aorta. Addict Health 2013; 5(3-4): 83-9.
  16. Elnimr T, Hashem A, Assar R. Heroin dependence effects on some major and trace elements. Biol Trace Elem Res 1996; 54(2): 153-62.
  17. Laso FJ, Madruga I, Borras R, Bajo A, Gonzalez-Buitrago JM, de Castro S. Hypokalemia in opiate overdose. Clin Investig 1994; 72(6): 471.
  18. Laso FJ, Gonzalez-Buitrago JM, Martin-Ruiz C, Vicens E, Moyano JC. Inter-relationship between serum potassium and plasma catecholamines and 3':5' cyclic monophosphate in alcohol withdrawal. Drug Alcohol Depend 1990; 26(2): 183-8.
  19. Liu IM, Cheng JT. Mediation of endogenous beta-endorphin in the plasma glucose-lowering action of herbal products observed in type 1-like diabetic rats. Evid Based Complement Alternat Med 2011; 2011: 987876.
  20. Karam GA, Rashidinejad HR, Aghaee MM, Ahmadi J, Rahmani MR, Mahmoodi M, et al. Opium can differently alter blood glucose, sodium and potassium in male and female rats. Pak J Pharm Sci 2008; 21(2): 180-4.
  21. Radosevich PM, Williams PE, Lacy DB, McRae JR, Steiner KE, Cherrington AD, et al. Effects of morphine on glucose homeostasis in the conscious dog. J Clin Invest 1984; 74(4): 1473-80.
  22. Brase DA, Singha AK, Estrada U, Lux F, Dewey WL. Hypoglycemia induced by intrathecal opioids in mice: stereospecificity, drug specificity and effect of fasting. J Pharmacol Exp Ther 1990; 253(3): 899-904.
  23. Azod L, Rashidi M, Afkhami-Ardekani M, Kiani G, Khoshkam F. Effect of opium addiction on diabetes. Am J Drug Alcohol Abuse 2008; 34(4): 383-8.
  24. Karam GA, Reisi M, Kaseb AA, Khaksari M, Mohammadi A, Mahmoodi M. Effects of opium addiction on some serum factors in addicts with non-insulin-dependent diabetes mellitus. Addict Biol 2004; 9(1): 53-8.
  25. Gozashti MH, Yazdi F, Salajegheh P, Dehesh MM, Divsalar K. Fasting blood glucose and insulin level in opium addict versus non-addict individuals. Addict Health 2015; 7(1-2): 54-9.
  26. Divsalar K, Meymandi MS, Afarinesh M, Zarandi MM, Haghpanah T, Keyhanfar F, et al. Serum biochemical parameters following heroin withdrawal: an exploratory study. Am J Addict 2014; 23(1): 48-52.
  27. Divsalar K, Meymandi MS, Saravani R, Zarandi MM, Shaikh-Al-Eslami A. Electrophoretic profile of serum proteins in opium and heroin dependents. Am J Drug Alcohol Abuse 2008; 34(6): 769-73.
Addiction & Health
Volume 8, Issue 4 - Serial Number 4
20
December 2016
Pages 211-217

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