Background: Positive perfectionism helps the individual to experience fewer worries and less anxiety. The aim of the present study was to assess the value of coping strategies to predict perfectionism in drug-user women. Methods: This cross-sectional study was performed on 361 consecutive drug-user women who were randomly selected from a total of 6237 women referring to the Drug Abuse Centers of Kerman, Iran, in 2013. Data were gathered using the positive and negative perfectionism scale, and coping responses questionnaire. Findings: There were significant correlations between positive and negative perfectionism with coping strategies problem-focused and emotional-focused (P < 0.001). Using multivariate regression modeling, 12% of total mental health variances could be estimated from metacognition beliefs. Conclusion: The positive and negative perfectionism can be rolled both as the predictors of coping strategies in drug-user women.