Kerman University of Medical Sciences

Document Type: Original Article(s)

Authors

1 Assistant Professor, Neuroscience Research Center, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

2 Associate Professor, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

3 Associate Professor, Research Center of Modeling in Health, Kerman University of Medical Sciences, Kerman, Iran.

4 Resident, Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

5 Ministry of Health and Medical Sciences, Tehran, Iran.

6 Research Assistant, Research Center of Modeling in Health, Kerman University of Medical Sciences, Kerman, Iran.

7 Ministry of Education, Tehran, Iran.

Abstract

Background: This study aimed to investigate the initial dosage of methadone and factors affecting it in maintenance therapy.Methods: This cross-sectional, descriptive-analytic study was conducted on 157 individuals referring to a methadone maintenance therapy (MMT) clinic. The initial dosage of methadone was 20-45 mg which was adjusted during the treatment based on each patient's evaluation. Three groups were formed according to methadone dosage (less than 30 mg, between 30-50 mg, and more than 50 mg).Findings: Significant relations were observed between increased methadone dosage in the initial phase and marital status (P = 0.03), injection (P = 0.03), medical comorbidity (P = 0.009), and borderline personality disorder (P < 0.001).Conclusion: Further studies with larger sample size and including the history of previous detoxification, substance abuse, omission of self-recording, evaluation of women’s addiction and MMT program performance with counseling support should be performed.Keywords: Addiction, Methadone, Personality disorder.