TY - JOUR ID - 84671 TI - Impact of Opium Addiction on Levels of Pro- and Anti-inflammatory Cytokines after ‎Surgery JO - Addiction and Health JA - AHJ LA - en SN - 2008-4633 AU - Lashkarizadeh, Mohammad Reza AU - Garshasbi, Mohammad AU - Shabani, Moahmmad AU - Dabiri, Shahriar AU - Hadavi, Hadi AU - Manafi-Anari, Hasan AD - ‎Associate Professor, Department of Surgery, School of Medicine AND Afzalipour Hospital, Kerman ‎University of Medical Sciences, Kerman, Iran AD - ‎Surgeon, Department of Surgery, School of Medicine AND Afzalipour Hospital, Kerman University of ‎Medical Sciences, Kerman, Iran AD - ‎Associate Professor, Neuroscience Research Center, Institute of Neuropharmacology, Kerman ‎University of Medical Sciences, Kerman, Iran AD - ‎Professor, Department of Pathology, School ‎of Medicine, Kerman University of Medical Sciences, ‎Kerman, Iran AD - Assistant Professor, ‎Department of Pathology, School of Medicine, Kerman University of Medical Sciences, ‎Kerman, Iran Y1 - 2015 PY - 2015 VL - 8 IS - 1 SP - 9 EP - 15 KW - Cytokines KW - Interleukins KW - opium addiction KW - laparotomy KW - Rat‎ DO - N2 - Background: Opium addiction alters immune responses to stresses such as an injury due to changing the secretion of cytokines. The present study assessed the effect of opium addiction on the cytokines [tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), interleukin-4 (IL-4), and IL-10] before and after laparotomy. Methods: Male rats were randomly divided into control and opium addicted (n = 20). Then, cytokines were measured before surgery, immediately after surgery (within 30-60 minutes) and 24 hours after surgery. Findings: IFN-γ was raised in an addicted group in three phases of the study as compared to that of the control group. IL-4 in opium addicted group decreased in two phases after surgery compared to the control group. IL-4 was lower after surgery in comparison to before surgery in the opium addicted group. The difference in IL-10 and TNFα levels was not statistically significant in the all groups measured in three phases of the investigation. Conclusion: The results revealed that opium addiction can increase plasma level of IFN-γ in rats and decrease plasma level of IL-4 after surgical stress. It seems that opium addicted rats are a more susceptible to increased inflammation. UR - https://ahj.kmu.ac.ir/article_84671.html L1 - https://ahj.kmu.ac.ir/article_84671_d4fe6fed59641da78eff05f3d485beef.pdf ER -