TY - JOUR ID - 84617 TI - Ginger (Zingiber Officinale Roscoe) Prevents Morphine-Induced Addictive Behaviors in Conditioned Place Preference Test in Rats JO - Addiction and Health JA - AHJ LA - en SN - 2008-4633 AU - Torkzadeh-Mahani, Shima AU - Nasri, Sima AU - Esmaeili-Mahani, Saeed AD - Associate Professor, Department of Biology, Payame Noor University, Tehran Branch, Tehran AND Laboratory of Molecular, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran AD - Associate Professor, Department of Biology, Payame Noor University, Tehran Branch, Tehran, Iran AD - Associate Professor, Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran Y1 - 2014 PY - 2014 VL - 6 IS - 1-2 SP - 65 EP - 72 KW - Ginger extract KW - Morphine KW - Conditioned place preference KW - Addictive seeking behavior KW - Rats DO - N2 - Background: Consumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-oxidative and antinociceptive properties. However, its influences on morphine-induced addictive behaviors have not yet been clarified. Methods: For conditioning to the morphine, the male Wistar rats received morphine (12 mg/kg intraperitoneally or i.p.) for 6 consecutive days and treatment groups were given different doses of ginger (25, 50 and 100 mg/kg intragastrically or i.g.) 30 min before morphine injection. For investigating addictive seeking behavior, conditioned place preference test (CPP) was used. Findings: Our result demonstrated that injection of morphine for 6 days induces dependency to morphine and creates addictive seeking behavior and ginger (100 mg/kg) could decrease time spend in conditioning box (addictive seeking behavior). Conclusion: The data indicated that ginger extract has a potential anti-addictive property against chronic usage of morphine. UR - https://ahj.kmu.ac.ir/article_84617.html L1 - https://ahj.kmu.ac.ir/article_84617_e016a94a0dcb915e580f32defd07094e.pdf ER -